SEMINAR: Omnis contra omnes – How can ticks overcome host adaptive immunity activated by other ticks?
od 15:00 do 15:00
|Přidat událost do kalendáře||
vKalendář (Windows, Linux)
iCal (Mac OS X)
Ticks are important and almost ubiquitous hematophagous ectoparasites and vectors of numerous microbial pathogens. As ticks feed on their hosts for several days they are in an intensive contact with hosts´ immune system leading to development of acquired tick immunity in some (but not all) host species. The “Golden Grail” of tick biology is to develop a tick vaccine which would induce such tick resistance in humans and domestic animals preventing tick feeding itself and subsequently also transmission of tick-borne pathogens. To achieve this goal, we need to understand expression profile and immunomodulatory effect of proteins and other chemical compounds present in tick saliva (tick sialome) and how does the sialome differs between various tick stages, individuals and during the process of tick feeding. The talk will summarize our current knowledge about this problematic and show the progress in development of tick vaccines.