Seminar: prof. Levi Yant

Čas	12.12.2023 od 15:00 do 16:30
Přiložený soubor:	2023_ZS_seminar_09_Yant.pdf
Přidat událost do kalendáře	Google vKalendář (Windows, Linux) iCal (Mac OS X)

The polyploid paradox: how successful new lineages are born, despite challenges to core process ranging from meiosis, to ion homeostasis, to cell size

Prof. Levi Yant

(University of Nottingham, and from Jan 2024 Charles University)

Join us online: meet.google.com/qhf-etyu-sna

Whole genome duplication (WGD) occurs in all kingdoms, causes immediate speciation, and is associated with novel adaptations and speciation. In fact, WGD triggers phenomena ranging from rapid species invasions to glioma metastasis. But WGD is an instant process, occurring in a single generation, and is a severe trauma to the cell; thus, it is usually fatal for lineages. In autopolyploids (within-species WGD, without hybridisation), sudden duplication of all chromosomes disrupts core processes, especially meiosis, DNA repair and ion homeostasis. Nevertheless, the rare hopeful monster that survives WGD is somehow special, on occasion experiencing runaway evolutionary success.

This leaves a ‘polyploid paradox’: WGD-mediated adaptability for some, despite serious challenges to core processes. Our work revealed a convergent basis of adaptation to WGD to consist of rapid, nimble shifts in genome management and DNA repair in 4 successful polyploids. I give an overview of our work following these lineages as they invade new habitats, tracing the sources of their adaptive variation, and then I outline two of our novel current working hypotheses to address the mechanistic basis for the sometimes remarkable adaptability of polyploids.

CV of the speaker HERE.