26. 3. 2024

Plant transmembrane formins - from actin nucleators to active cargoes of membrane trafficking

prof. RNDr. Fatima Cvrčková, Dr. rer. nat.

(Faculty of Science - Department of Experimental Plant Biology)

Připojte se online: meet.google.com/qhf-etyu-sna

Formins are a large, evolutionarily old family of cytoskeletal regulators whose roles include actin capping and nucleation, as well as modulation of microtubule dynamics. Plant class I formins are characterized by a unique domain organization found in no other lineage, as most of them are transmembrane proteins with possible cell wall-binding motifs exposed to the extracytoplasmic space. Although such transmembrane formins are traditionally considered mainly as plasmalemma-localized proteins contributing to the organization of the cell cortex, they could also, at least temporarily, reside in endomembranes. Building on published data and our lab´s results, I will discuss a model where class I formins may serve as “active cargoes” of membrane trafficking, i.e. membrane-embedded proteins that modulate the fate of membrane compartments they reside on.