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Doc. RNDr. Jiří Novotný, DSc.


Funkční zařazení: docent

  • vedoucí katedry fyziologie
  • vedoucí skupiny membránových receptorů a buněčné signalizace


Výuka (odkaz do SISu)


Vědecké zaměření

fyziologie nervového systému a srdce, molekulární mechanismy buněčné signalizace (zejména struktura a funkce signálních systémů receptorů spřažených s G proteiny), zkoumání molekulárních mechanismů kardioprotektivního působení chronické hypoxie, chladové adaptace nebo ischemického preconditioningu, studium buněčné signalizace, cytoprotekce, oxidativního stresu a apoptózy v souvislosti s působením opioidů


Vybrané publikace za posledních 5 let

Ujcikova H, Hejnova L, Eckhardt A, Roubalova L, Novotny J, Svoboda P. (2021) Impact of three-month morphine withdrawal on rat brain cortex, hippocampus, striatum and cerebellum: proteomic and phosphoproteomic studies. Neurochem Int. 144:104975. doi: 10.1016/j.neuint.2021.104975. 

Honetschlagerová Z, Gawrys O, Jíchová Š, Škaroupková P, Kikerlová S, Vaňourková Z, Husková Z, Melenovský V, Kompanowska-Jezierska E, Sadowski J, Kolář F, Novotný J, Hejnová L, Kujal P, Červenka L. (2021) Renal Sympathetic Denervation Attenuates Congestive Heart Failure in Angiotensin II-Dependent Hypertension: Studies with Ren-2 Transgenic Hypertensive Rats with Aortocaval Fistula. Kidney Blood Press Res. 46(1):95-113. doi: 10.1159/000513071. 

Moravcová S, Červená K, Míková H, Pačesová D, Pallag G, Novotný J, Bendová Z. (2021) Social defeat stress affects resident's clock gene and bdnf expression in the brain. Stress. 24(2):206-212. doi: 10.1080/10253890.2020.1759548. 

Tibenska V, Marvanova A, Elsnicova B, Hejnova L,  Vebr P, Novotný J, Kolar F, Novakova O, Zurmanova JM. (2021) The cardioprotective effect persisting during recovery from cold acclimation is mediated by the β 2-adrenoceptor pathway and Akt activation. J Appl Physiol (1985).;130(3):746-755. 

Drastichova Z, Rudajev V, Pallag G, Novotny J. (2021) Proteome profiling of different rat brain regions reveals the modulatory effect of prolonged maternal separation on proteins involved in cell death-related processes. Biol Res. 54(1):4. doi: 10.1186/s40659-021-00327-5.

Drastichova Z, Hejnova L, Moravcova R, Novotny J. (2021) Proteomic Analysis Unveils Expressional Changes in Cytoskeleton- and Synaptic Plasticity-Associated Proteins in Rat Brain Six Months after Withdrawal from Morphine. Life (Basel). 11(7):683. doi: 10.3390/life11070683.

Tibenská V, Benesova A, Vebr P, Liptáková A, Hejnová L, Elsnicová B, Drahota Z, Hornikova D, Galatík F, Kolar D, Vybiral S, Alánová P, Novotný J, Kolar F, Novakova O, Zurmanova JM. (2020) Gradual cold acclimation induces cardioprotection without affecting beta-adrenergic receptor-mediated adenylyl cyclase signaling. J Appl Physiol (1985).;128(4):1023-1032.

Rudajev V, Novotny J. (2020) The Role of Lipid Environment in Ganglioside GM1-Induced Amyloid β Aggregation. Membranes (Basel). Sep 9;10(9):226.

Spišská V, Pačesová D, Míková H, Pohanová P, Telenský P, Novotný J, Bendová Z. (2020) Prenatal exposure to lipopolysaccharide induces changes in the circadian clock in the SCN and AA-NAT activity in the pineal gland. Brain Res. 1743:146952. doi: 10.1016/j.brainres.2020.146952. 

Bendová Z, Pačesová D, Novotný J. (2020) The day-night differences in ERK1/2, GSK3β activity and c-Fos levels in the brain, and the responsiveness of various brain structures to morphine. J Comp Neurol. 528(14):2471-2495. doi: 10.1002/cne.24906. 

Melkes B, Markova V, Hejnova L, Marek A, Novotny J. (2020) Naloxone Is a Potential Binding Ligand and Activator of the Capsaicin Receptor TRPV1. Biol Pharm Bull. 43(5):908-912. doi: 10.1248/bpb.b19-00806.

Melkes B, Markova V, Hejnova L, Novotny J. (2020) β-Arrestin 2 and ERK1/2 Are Important Mediators Engaged in Close Cooperation between TRPV1 and µ-Opioid Receptors in the Plasma Membrane. Int J Mol Sci. 21(13):4626. doi: 10.3390/ijms21134626.

Filipovská E, Červená K, Moravcová S, Novotný J, Kyclerová H, Spišská V, Pačesová D, Bendová Z. (2019) The effect of the cannabinoid receptor agonist and antagonist on the light-induced changes in the suprachiasmatic nucleus of rats. Neurosci Lett. 703:49-52. doi: 10.1016/j.neulet.2019.03.022. 

Cockova Z, Ujcikova H, Telensky P, Novotny J. (2019) Protein profiling of SH-SY5Y neuroblastoma cells: The effect of rhein. J Biosci. 44(4):88.

Manakov D, Kolar D, Zurmanova J, Pravenec M, Novotny J. (2018) Changes in the activity of some metabolic enzymes in the heart of SHR rat incurred by transgenic expression of CD36. J Physiol Biochem. [Epub ahead of print] PubMed PMID: 29916179.

Nedvedova I, Kolar D, Elsnicova B, Hornikova D, Novotny J, Kalous M, Pravenec M, Neckar J, Kolar F, Zurmanova JM. (2018) Mitochondrial genome modulates myocardial Akt/GLUT/HK salvage pathway in spontaneously hypertensive rats adapted to chronic hypoxia.  Physiol Genomics. 50(7):532-541.

Skrabalova J, Karlovska I, Hejnova L, Novotny J. (2018) Protective Effect of Morphine Against the Oxidant-Induced Injury in H9c2 Cells. Cardiovasc Toxicol. 18(4):374-385. doi: 10.1007/s12012-018-9448-0.

Moravcová S, Pačesová D, Melkes B, Kyclerová H, Spišská V, Novotný J, Bendová Z. (2018) The day/night difference in the circadian clock's response to acute lipopolysaccharide and the rhythmic Stat3 expression in the rat suprachiasmatic nucleus. PLoS One. 2018 Sep 28;13(9):e0199405. doi: 10.1371/journal.pone.0199405. eCollection 2018.

Hahnova K, Brabcova I, Neckar J, Weissova R, Svatonova A, Novakova O, Zurmanova J, Kalous M, Silhavy J, Pravenec M, Kolar F, Novotny J. (2018) β-Adrenergic signaling, monoamine oxidase A and antioxidant defence in the myocardium of SHR and SHR-mtBN conplastic rat strains: the effect of chronic hypoxia. J Physiol Sci. 68(4):441-454.

Míčová P, Klevstig M, Holzerová K, Vecka M, Žurmanová J, Neckář J, Kolář F, Nováková O, Novotný J, Hlaváčková M. (2017) Antioxidant tempol suppresses heart cytosolic phospholipase A2α stimulated by chronic intermittent hypoxia. Can J Physiol Pharmacol. Aug;95(8):920-927

Neckar J, Svatonova A, Weissova R, Drahota Z, Zajickova P, Brabcova I, Kolar D, Alanova P, Vasinova J, Silhavy J, Hlavackova M, Tauchmannova K, Milerova M, Ostadal B, Cervenka L, Zurmanova J, Kalous M, Novakova O, Novotny J, Pravenec M, Kolar F. (2017) Selective replacement of mitochondrial DNA increases cardioprotective effect of chronic continuous hypoxia in spontaneously hypertensive rats. Clin Sci (Lond). May 1;131(9):865-881

Kolar D, Gresikova M, Waskova-Arnostova P, Elsnicova B, Kohutova J, Hornikova D, Vebr P, Neckar J, Blahova T, Kasparova D, Novotny J, Kolar F, Novakova O, Zurmanova J. (2017) Adaptation to chronic continuous hypoxia potentiates Akt/HK2 anti-apoptotic pathway during brief myocardial ischemia/reperfusion insult. Mol Cell Biochem. Aug;432(1-2):99-108. 

Micova P, Hahnova K, Hlavackova M, Elsnicova B, Chytilova A, Holzerova K, Zurmanova J, Neckar J, Kolar F, Novakova O, Novotny J. (2016) Chronic intermittent hypoxia affects the cytosolic phospholipase A2α/cyclooxygenase 2 pathway via β2-adrenoceptor-mediated ERK/p38 stimulation. Mol Cell Biochem. 423(1-2):151-163. 

Pačesová D, Novotný J, Bendová Z. (2016) The effect of chronic morphine or methadone  exposure and withdrawal on clock gene expression in the rat suprachiasmatic nucleus and AA-NAT activity in the pineal gland. Physiol Res. 18;65(3):517-25. 

Hahnova K, Kasparova D, Zurmanova J, Neckar J, Kolar F, Novotny J. (2016) β-Adrenergic signaling in rat heart is similarly affected by continuous and intermittent normobaric hypoxia. Gen Physiol Biophys. 35(2):165-73.

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