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Laboratory of Cancer Cell Invasion

Group leaders: Prof. RNDr. Jan Brábek, PhD., RNDr. Daniel Rösel, PhD.

Web pages of the research group: http://web.natur.cuni.cz/cellbiol/invalab/;

Research statement

The most dangerous aspect of most cancers is the ability of tumor cells to form secondary foci, so-called metastases. Although cells must undergo various processes for successful metastasis, the invasion of cells from the original tumor into the surrounding tissue is generally considered the critical step. Three main invasion strategies of tumor cells when overcoming the surrounding tissue have been described: mesenchymal, collective and amoeboid. Mesenchymal and collective modes of invasion are characterized by proteolytically dependent remodeling of surrounding tissue and integrin-mediated contacts. Amoeboid invasion is independent of proteolysis and integrin signaling and is characterized by increased Rho kinase ROCK activity.

The Laboratory of Cancer Cell Invasion was founded in 2006 at the Department of Cell Biology and studies molecular processes and morphological changes that give the transformed cell its ability to effectively invade the surrounding tissue. We are currently investigating the molecular aspects of individual invasion modes using a variety of advanced experimental approaches, including high-resolution microscopy, 3D cell culture, Crispr KO clone generation and analysis, protein and gene expression analysis, and subcellular protein activity detection using biosensors.

For updated information on research projects and vacancies, visit our group website.



Brábek Jan (Prof.RNDr.,Ph.D.)
BIOCEV; +420 325873900; brabek@natur.cuni.cz

Rősel Daniel (Doc.RNDr.,Ph.D.)
BIOCEV; +420 325873900; rosel@natur.cuni.cz

Where to find our laboratory: BIOCEV (Průmyslová 595, 252 50 Vestec); room A2.103

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