The plaques of amyloid fibrils are the hallmark of several neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s disease. As our society gets older, these diseases become more widespread, causing immense difficulties not only for patients but also for their close friends and relatives. The selective imaging of amyloid fibrils is therefore crucial for studying the mechanism of their development but has encountered multiple obstacles. A small fluorescent dye developed by scientists from the Institute of Organic Chemistry and Biochemistry of Czech Academy of Sciences and the Faculty of Science of Charles University, led by Dr. Pankaj Gaur, could therefore be a new hope for imaging the amyloid fibrils in living cells.
Published Oct 11, 2021