The results of projects supported by the Czech-Norwegian Research Programme were presented at our faculty
Use of long-term (passive) sampling methods in combination with in situ microcosms to assess potential (bio)degredation.
Project number and acronym: 7F14045 (PASSES)
Investigator: doc. RNDr. Tomáš Cajthaml, Ph.D.
Norwegian partner: ALS Norway
Additional project partner: Dekonta a.s.
Project website: http://passes.cz/
The project examined environmental pollution and its elimination using bacteria, a process known as bioremediation. To verify whether in situ biodegredation of contaminants is occurring, and whether these ongoing processes are sufficiently effective or can be enhanced to replace conventional remediation technologies, it is essential to gain a comprehensive understanding of the biodegredation processes that are specific for a given location. The project focused on the characterization of such processes by using innovative monitoring approaches such as passive sampling and in situ microcosms. The project produced numerous scientific publications as well as verified technology and a utility model.
Genomics of three-dimensional yeast colonies: A model to study the development of tumours and resistance of biofilms
Project number and acronym: 7F14083 (YEASTSEQ)
Investigator: prof. RNDr. Zdena Palková, CSc.
Norwegian partner: Sequencing Centre, University Hospital in Oslo, Dr. Gregor Gilfillan
Project website: http://www.3dcolony.cz
The joint project between the Institute of Microbiology of the Czech Academy of Sciences and the University Hospital in Oslo was based on the findings of Czech teams that yeast colonies behave similarly to simple, single-celled organisms and that many metabolic parallels exist between differentiated yeasts colonies and organisms afflicted by tumorous growths. The project yielded detailed descriptions of the processes of metabolic differentiation in colonies, identified mutations beneficial to cell subpopulations exposed to specific conditions, examined epigenetic regulation affecting the development of colony phenotypes, and expanded knowledge of differences in chromatin structure in different strains/colonies. Other findings clarified the sophisticated defensive strategy of biofilm yeast colonies. The knowledge obtained during this project and published in international scientific journals has potential application in medicine, especially the physiology of tumours and treatment of mycoses.
Phosphine ligands for environmentally friendly C-C binding reactions
Project number and acronym: 7F14392 (ENVIPHOS)
Investigator: prof. RNDr. Petr Štěpnička, Ph.D.
Norwegian partner: University of Bergen (Professor Vidar Remi Jensen)
Project website: http://web.natur.cuni.cz/~uhlik1/index_cz
This project, conducted in cooperation with the team of Professor V. R. Jensen at the University of Bergen, was primarily aimed at improving the design of new ligands for practical major binding reactions carried out in environmentally-friendly aqueous environments using a combination of conventional experimental approaches and modern computational chemistry methods. An entire range of new compounds were prepared, thoroughly characterized, and of course also tested in select palladium-catalysed reactions. The project results were published in professional journals and also presented in numerous conference papers.