How Trypanosoma escaped the immunity
Trypanosoma brucei gambiense is responsible for over 95 % of sleeping sickness cases – a disease that threatens many inhabitants of Africa. Like any parasite, Trypanosoma is trying to escape the human immune system quite successfully, despite being exposed to the hostile environment of the intravascular system. Its elaborate mechanisms against adaptive immunity have been described but how does this parasite outsmart the early stages of immune response? An international research group, joined by Martin Zoltner from the Faculty of Science, Charles University, tried to answer that question.
Published Aug 14, 2023