Our Yeast research experts have received a prestigious Czech-American grant under the INTER-EXCELLENCE programme
The research of the Yeast Colony Group was recognised by the award of grant support under the INTER-ACTION LTA USA18 section of INTER-EXCELLENCE programme. The international collaboration project was awarded to Prof. Z. Palková (Charles University, Faculty of Science, BIOCEV) and Dr. L. Váchová (Institute of Microbiology, CAS, BIOCEV) together with the collaborating team of Prof. T. G. Cooper from the University of Tennessee, USA. The project focuses on research of central regulatory mechanisms connecting signals from the environment with cell metabolic reprogramming and ageing.
Regulatory proteins mediating such signalling are among the most evolutionary conserved proteins in eukaryotic organisms. Understanding of their function in relatively simple yeast model thus could contribute to identification of new regulations in metazoa. The TORC1 complex is one of the most important central regulators conserved from yeast to mammalian cells, which controls the cell metabolic reprogramming in response to environmental conditions. The understanding of metabolic regulations related to cell ageing and differentiation in response to various environmental conditions thus offers the prospect of identifying new targets for treatment of several diseases, including cancer.