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Secretion-regulating proteins in plants influence resistance to pathogens

The first joint author of a recently published study in the prestigious journal Plant Cell is PhD student from the Faculty of Science, George Caldarescu.

A wide variety of pathogenic bacteria and fungi cause 20%-30% of crop losses worldwide; another 12% of losses occur during storage and transport. Better than chemical protection are genes that ensure resistance against pathogens. MLO genes (mildew resistance locus o) are plant specific and their loss-of-function mutations surprisingly show excellent resistance to powdery mildew fungi in various crops without significant yield reduction. Until very recently, it was not known how membrane MLO proteins function at the molecular level. Supported by the GAČR-DFG joint project the research group of prof. Viktor Žárský in cooperation with the group of prof. Ralph Panstruga in Aachen discovered a new interaction and cooperation of MLO proteins with the exocyst complex - regulator of protein secretion to the cell surface playing an important role also in plant defense against pathogens.

Prof. Žárský and George Caldarescu; author: Ali B. Yildiz 
Trichome; author: George Caldarescu


Link to the study: (DOI: 10.1093/plcell/koad319)

Published: Jan 19, 2024 07:05 PM

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