Quo Vadis Chemie: Supramolecular Fluorescence-Based Sensing

When	Feb 26, 2018 from 03:00 PM to 06:00 PM
Contact Name	martin.kotora@natur.cuni.cz
Contact Phone	+420 221 95 1058
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Supramolecular Assay for Carbonic Anhydrase Enzymes Inhibitors. In this presentation we will describe how sulfonamide inhibitors associate with CA and how this feature is utilized in the design of fluorescent sensing ensembles that allow to measure affinity of various CA inhibitors for the enzyme.

Determination of Enantiomeric Excess in 1,2- and 1,3-Diols. Our approach to determine the enantiomeric excess (ee) utilizes self-assembled iminoboronate esters formed as a product of dynamic covalent self-assembly of a chiral diol with an enantiopure fluorescent amine. The resulting diastereomeric boronate assemblies display different photophysical properties and allow for fluorescence-based ee determination of molecules containing a 1,2- or 1,3-diol moiety.

The lecture will be delivered by:

Prof. Pavel Anzenbacher, Jr.

The Institute of Scientific and Industrial Research Osaka University, Japan

The Lecture Hall CH2, the School of Chemistry Building, FoS CU, Hlavova 8, Praha 2