E-mail | SIS | Moodle | Helpdesk | Libraries | cuni.cz | CIS More

česky | english Log in



Our Yeast research experts have received a prestigious Czech-American grant under the INTER-EXCELLENCE programme

The Yeast Colony Group team has been awarded grant support from INTER-EXCELLENCE programme for a new project of international research and development aimed at Czech-American collaboration. Supported project focuses on research into the molecular mechanisms of cell adaptation connected with cell aging, one of the most important questions in current biology. Regulatory proteins mediating cellular response to extracellular signals are among the most evolutionary conserved proteins in eukaryotes. Understanding of their function in relatively simple yeast model thus could contribute to identification of new regulations in metazoa.

 

Two morphologically distinct cell subpopulations of U and L cells are visible on yeast colony cross-section. U cells with an active TORC1 pathway are metabolically active cells with longevity phenotype. These cells benefit from nutritive compounds provided by L cell subpopulation localized in lower colony regions.

 

The research of the Yeast Colony Group was recognised by the award of grant support under the INTER-ACTION LTA USA18 section of INTER-EXCELLENCE programme. The international collaboration project was awarded to Prof. Z. Palková (Charles University, Faculty of Science, BIOCEV) and Dr. L. Váchová (Institute of Microbiology, CAS, BIOCEV) together with the collaborating team of Prof. T. G. Cooper from the University of Tennessee, USA. The project focuses on research of central regulatory mechanisms connecting signals from the environment with cell metabolic reprogramming and ageing.

Regulatory proteins mediating such signalling are among the most evolutionary conserved proteins in eukaryotic organisms. Understanding of their function in relatively simple yeast model thus could contribute to identification of new regulations in metazoa. The TORC1 complex is one of the most important central regulators conserved from yeast to mammalian cells, which controls the cell metabolic reprogramming in response to environmental conditions. The understanding of metabolic regulations related to cell ageing and differentiation in response to various environmental conditions thus offers the prospect of identifying new targets for treatment of several diseases, including cancer.

 

Published: Nov 30, 2018 11:50 AM

Document Actions