Research

The key research activities at the Department of Biochemistry is concentrated in key directions dealing with protein biochemistry and engineering, studies on biological activities of glycoproteins and glycolipids, computer modeling of biochemical interactions, detailed investigations of the molecular mechanisms of antitumor drug action and development, enzymology of hemoproteins (cytochromes P450 and peroxidases) pertinent to drug metabolism and studies on proteases of human pathogens. The scientific endeavor is concentrated mainly into the research groups of Prof. Petr Hodek, Prof. Helena Ryšlavá, Prof. Jan Konvalinka, Assoc. Prof. Miroslav Šulc,  Assoc. Prof. Olga Heidingsfeld, and Dr. Radek Indra.

Laboratory of biomolecule structure and function

Research Groups:

• Structure-functional proteomics of biomolecules (Head - Assoc. Prof. Šulc)
• Structural biochemistry and cell signaling (Head - Dr. Novák)
• Modeling of Biomolecules (Head - Assoc. Prof. Martínek)
• Laboratory of Structural Biochemistry of Immune Recognition (Head - Dr. Vaněk)

Laboratory of molecular carcinogenesis and drug development

Research Groups:

• Laboratory of molecular carcinogenesis and drug development (Head - Dr. Indra)
• Modulation of key biotransformation enzymes by xenobiotics (Head - Prof. Hodek)
• Laboratory of heme-containing sensor proteins (Head - Assoc. Prof. Martínková)

Laboratory of cystic fibrosis pathogenesis

Research Groups:

• Profylaxis of microbial infections in CF (Head - Prof. Hodek)
• Molecular basis of bacterial adherence in CF (Head - Msc. Kubíčková)

Laboratory of plant biochemistry and regulation

Research Groups:

• Biochemistry of Plants (Head - Prof. Ryšlavá)

Laboratory of Biochemistry of Pathogenic Yeasts

Research Groups:

• Biochemistry of Pathogenic Yeasts (Head - Assoc. Prof. Heidingsfeld)

Laboratory of proteases of human pathogens

Research Groups:

• Proteases of human pathogens (Head - Prof. Konvalinka)