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Research Activities

The key research activities at the Department of Biochemistry is concentrated in key directions dealing with protein biochemistry and engineering, studies on biological activities of glycoproteins and glycolipids, computer modeling of biochemical interactions, detailed investigations of the molecular mechanisms of antitumor drug action and development, enzymology of hemoproteins (cytochromes P450 and peroxidases) pertinent to drug metabolism and studies on proteases of human pathogens. The scientific endeavor is concentrated mainly into the research groups of Prof. Marie Stiborová, Assoc. Prof. Miroslav Šulc, Assoc.Prof. Jan Konvalinka, Assoc.Prof. Helena Ryšlavá and Dr. Klára Hlouchová.

Laboratory of biomolecule structure and function - (Assoc. Prof. Šulc)

Team members - Šulc, Novák, Man, Martínek, Martínková, Vaněk, Kavan, Chmelík, Hudeček, Jeřábek, Pompach, Vališ

Laboratory of molecular carcinogenesis and drug development – (Prof. Stiborová)

Team members - Stiborová, Hudeček. Hodek, Šulc, Martínek, Martínková, Bořek-Dohalská, Svášková, Dračínská, Poljaková, Novák, Černá, Moserová, Jeřábek

Laboratory of plant biochemistry and regulation (Assoc. Prof. Ryšlavá)

Team members - Ryšlavá, Doubnerová, Poljaková, Svášková, Novák, Vališ

Laboratory of proteases of human pathogens (Assoc. Prof. Konvalinka)

Team members – Konvalinka, Ingr, Hlouchová, Schimer, Šácha

Synthetic and evolutionary biochemistry (Dr. Hlouchová)

Team members – Valerio Guido Giacobelli, Vjačeslav Treťjačenko, Jiří Vymětal, Helena Jindrová, Barbora Ptáčková

 

The development of the advanced research activities of the Department is illustrated by a number of scientific papers authored by members of the Department published in scientific journals.


Brief summary of international research activities by Department members and membership in domestic and international learned societies:

International Collaborations

- German Cancer Research Center, Heidelberg, Germany (Prof. Stiborová)
- King’s College London, UK (Prof. Stiborová)
- University of Texas, Houston,  USA (Prof. Stiborová, Prof. Hodek, Assoc. Prof. Šulc)
- Technische Universität Berlin, Germany (Prof. Hudeček)
- CNRS URA, Universite Louis Pastear, Strasbourg (Prof. Entlicher, Prof. Stiborová)
- Institute for Molecular Science, Okazaki, Japan (Prof. Hudeček)
- National Institute of Molecular Studies Okazaki, Japan (Prof. Hudeček)
- Hôpital Erasme, Brussels, Belgium (Prof. Stiborová)
- Universität  Lübeck, Germany (Assoc. Prof. Konvalinka)
- Cancer Research UK Molecular Pharmacology Unit, Biomedical Research Centre, Dundee,  UK (Prof. Stiborová)
- University of Cincinnati Medical Center, Cincinnati, USA (Prof. Stiborová)
- Tohoku University Sendai, Japan (Prof. Hudeček, Assoc. Prof. Martínková (born. Mikšanová))
- Loyola University, Chicago, USA  (Doc. Martínek)
- Saarland University, Saarbrücken, Germany (Prof. Stiborová, Prof. Hudeček, Prof. Hodek)
- CEDETO/Uni Centro, Parana, Brazil (Prof. Stiborová)
- Karolinska Institutet, Stockholm, Sweden (Assoc. Prof. Konvalinka)

- ELSI, Tokyo Institute of Technology, Japan (Dr. Klára Hlouchová)

 

Participation in national and international scientific organizations:

- Xenobiochemical section of the Czech and Slovak Society for Biochemistry and Molecular Biology (Prof. Stiborová – Chair)
-  Czech and Slovak Society for Biochemistry and Molecular Biology (Prof. Stiborová – Committee Member, Prof. Hudeček, Assoc. Prof. Ryšlavá, Assoc. Prof. Konvalinka)
- Czech Chemical Society (Prof. Stiborová, Assoc. Prof. Konvalinka, Assoc. Prof. Ryšlavá)
- European Academy of Science, Art, and Literature, France (Prof. Stiborová – Corresponding Member)
- Institute for Science and Health (USA) (Prof. Stiborová – Member of the Scientific Council)
- Learned Society of the Czech Republic (Assoc. Prof. Konvalinka)
- Editorial board of journal Collection of Czechoslovak Chemical Communications (Prof. Hudeček)
- Expert activities for EU within the frame of COST projects (Assoc. Prof. Konvalinka, Prof. Stiborová)
- Expert activities for Research Management Group, MA (USA) (Prof. Stiborová)
- Expert activities for Fonds zur Förderung der Wissenschaftlichen Forschung, Austria (Prof. Stiborová)
- Expert activities for grant agencies such as GAUK, GAČR, FRVŠ, IGA MZ ČR, MŠMT ČR a MŽP ČR projects (Prof. Entlicher, Prof. Hodek, Prof. Hudeček, Prof. Stiborová, , Prof. Hodek, Assoc. Prof. Konvalinka, Assoc. Prof. Ryšlavá, Dr. Liberda)

Organization of international conferences:

- Cytochrome P450, 29. 6. – 3. 7. 2003, Prague, Czech Republic (Prof. Hudeček, Prof. Hodek, Prof. Stiborová)
- From genes to Molecular Epidemiology, 2.7. – 5.7. 2006, Prague, Czech Republic (Prof. Stiborová)
- 17th International Mass Spectrometry Conference, 27.8-1.9. 2006, Prague, ČR (Assoc. Prof. Šulc, Dr. Novák, Dr. Man, Dr. Kavan, Dr. Pompach)
- Workshop on Biomarker of Exposure and Cancer Risk: DNA Damage and DNA Adduct Detection & 6th GUM-32P-Postlabelling Workshop”. 29. - 30.9.2006, Heidelberg, Germany (Prof. Stiborová)

- 2nd European Variety in Chemistry Education (Eurovariety 2007) 27. - 30. 6. 2007, Prague, Czech Republic (Dr. Martínek)

- Current Trends in Chemical Curricula (CTCC) (Současné trendy ve výuce chemie 2008), 24. - 26. 9. 2008 Prague, Czech Republic (Dr. Martínek)

Modern Electroanalytical Methods 2009 9. - 13. 12. 2009 Prague (Dr. Martínek)

34th FEBS Congress - 4. - 9. 2009 Prague, Czech Republic (Assoc. Prof. Konvalinka, Prof. Stiborová)

- 16th Interdisciplinary toxicology conference TOXCON 2011 - 17. - 20. 2011, Prague, ČR (Prof. Stiborová, Prof. Hudeček, Prof. Hodek)

- XXIII. biochemický sjezd - 26. – 29. 8. 2012, Brno, ČR (Prof. Stiborová)

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