Nabídka dizertační práce na téma "SUCLG2 as a new tumor suppressor affecting mitochondrial metabolism"

Many family cancer syndromes are caused by inherited mutations in tumor suppressor genes. We have recently identified new germline variants in the SUCLG2 gene which are associated with a rare type of neuroendocrine tumors, pheochromocytoma and paraganglioma (PPGL). SUCLG2 is a subunit of a citric acid cycle enzyme, succinyl-CoA ligase (SUCL), which has not been previously linked to cancer development. The objective of this project is to describe the effect of SUCLG2 variants found in PPGL patients on the function of SUCL and to delineate the mechanisms by which these mutations promote tumorigenesis. Since we found that malfunction of SUCLG2 leads to suppressed activity of a well-known PPGL tumor suppressor, mitochondrial complex II, the functional link between SUCLG2 and complex II will be investigated. The project will lead to validation of SUCLG2 as a novel tumor suppressor with important consequences for genetic counselling.

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(pozn.: i když je nabídka koncipována pro DSP Fyziologie, ve skutečnosti v laboratoři prof. Neužila velmi úspěšně studuje mnoho studentů v rámci DSP Molekulární a buněčná biologie, genetika a virologie, takže nabídku rozhodně mohou využít i uchazeči o tento doktorský studijní program!)