doc. RNDr. Jitka Žurmanová, Ph.D.

Funkční zařazení: odborný asistent

• vedoucí skupiny fyziologie svalů a signalizace chladové aklimace

Výuka (odkaz do SISu)

Vědecké zaměření

Studujeme vliv mírné chladové aklimace, neboli otužováním, na celý organismus v souvislosti s jejím protektivním působením na srdce, které jsme nedávno popsali. Naším cílem je porozumět molekulární podstatě chladové aklimace a najít model pro její klinické využití v prevenci i léčbě.

Vybrané publikace za posledních 5 let

Cizkova D, Zurmanova JM, Gerykova L, Kouvelas A, Heles M, Elsnicova B, Galatik F, Silhavy J, Pravenec M, Mokry J. (2023) Nestin expression in intact and hypertrophic myocardium of spontaneously hypertensive rats during aging J Muscle Res Cell Motil. 2023 Jan 24. doi: 10.1007/s10974-023-09641-9. Online ahead of print.
https://link.springer.com/content/pdf/10.1007/s10974-023-09641-9.pdf.

Elsnicova B^*, Hornikova D^*, Tibenska V, Kolar D, Tlapakova T, Schmid B, Mallek M, Eggers B, Schlötzer-Schrehardt U, Peeva V, Berwanger C, Eberhard B, Durmuş H, Schultheis D, Holtzhausen C, Schork K, Marcus K, Jordan J, Lücke T, van der Ven PFM, Schröder R, Clemen CS, Zurmanova JM. (2022) Desmin Knock-Out Cardiomyopathy: A Heart on the Verge of Metabolic Crisis. Int J Mol Sci. 2022 Oct 10;23(19):12020.

Benova TE, Viczenczova C, Szeiffova Bacova B, Zurmanova J, Knezl V, Andelova K, Tribulova K.
(2021) Omacor Protects Normotensive and Hypertensive Rats Exposed to Continuous Light from
Increased Risk to Malignant Cardiac Arrhythmias. Mar Drugs.;19(12):659.

Pravenec M, Silhavy J, Mlejnek P, Simakova M, Mracek T, Pecinova A, Tauchmannova, K, Hutl M, Malinska H, Kazdova L, Neckar J, Kolar F, Zurmanova J, Novotny J, Houstek, J. (2021) Conplastic Strains for Identification of Retrograde Effects of Mitochondrial DNA Variation on Cardiometabolic Traits in the Spontaneously Hypertensive Rat. Physiol Res;70(Suppl4):S471-S484.

Tibenska V, Marvanova A, Elsnicova B, Hejnova L,  Vebr P, Novotný J, Kolar F, Novakova O, Zurmanova JM. (2021) The cardioprotective effect persisting during recovery from cold acclimation is mediated by the β 2-adrenoceptor pathway and Akt activation. J Appl Physiol (1985).;130(3):746-755. 

Tibenská V, Benesova A, Vebr P, Liptáková A, Hejnová L, Elsnicová B, Drahota Z, Hornikova D, Galatík F, Kolar D, Vybiral S, Alánová P, Novotný J, Kolar F, Novakova O, Zurmanova JM. (2020) Gradual cold acclimation induces cardioprotection without affecting beta-adrenergic receptor-mediated adenylyl cyclase signaling. J Appl Physiol (1985).;128(4):1023-1032.

Sykora M, Szeiffova Bacova B, Egan Benova T, Barancik M, Zurmanova J, Rauchova H, Weismann P, Pavelka S, Kurahara LH, Slezak J, Soukup T, Tribulova N. (2019) Cardiac Cx43 and ECM Responses to Altered Thyroid Status Are Blunted in Spontaneously Hypertensive versus Normotensive Rats. Int J Mol Sci.;20(15). pii: E3758. 

Kohutova J, Elsnicova B, Holzerova K, Neckar J, Sebesta O, Jezkova J, Vecka M, Vebr P, Hornikova D, Szeiffova Bacova B, Egan Benova T, Hlavackova M, Tribulova N, Kolar F, Novakova O, Zurmanova JM. (2019) Anti-arrhythmic Cardiac Phenotype Elicited by Chronic Intermittent Hypoxia Is Associated With Alterations in Connexin-43 Expression, Phosphorylation, and Distribution. Front Endocrinol (Lausanne). 9:789. 

Nedvedova I, Kolar D, Neckar J, Kalous M, Pravenec M, Šilhavý J, Korenkova V, Kolar F, Zurmanova JM. (2019) Cardioprotective Regimen of Adaptation to Chronic Hypoxia. Front Endocrinol (Lausanne). 9:809.

Manakov D, Kolar D, Zurmanova J, Pravenec M, Novotny J. (2018) Changes in the activity of some metabolic enzymes in the heart of SHR rat incurred by transgenic expression of CD36. J Physiol Biochem. [Epub ahead of print] PubMed PMID: 29916179.

Nedvedova I, Kolar D, Elsnicova B, Hornikova D, Novotny J, Kalous M, Pravenec M, Neckar J, Kolar F, Zurmanova JM. (2018) Mitochondrial genome modulates myocardial Akt/GLUT/HK salvage pathway in spontaneously hypertensive rats adapted to chronic hypoxia.  Physiol Genomics. 50(7):532-541.

Hahnova K, Brabcova I, Neckar J, Weissova R, Svatonova A, Novakova O, Zurmanova J, Kalous M, Silhavy J, Pravenec M, Kolar F, Novotny J. (2018) β-Adrenergic signaling, monoamine oxidase A and antioxidant defence in the myocardium of SHR and SHR-mtBN conplastic rat strains: the effect of chronic hypoxia. J Physiol Sci. 68(4):441-454.