Doc. RNDr. Jiří Novotný, DSc.

Funkční zařazení: docent

• vedoucí katedry fyziologie
• vedoucí skupiny membránových receptorů a buněčné signalizace

Výuka (odkaz do SISu)

Vědecké zaměření

fyziologie nervového systému a srdce, molekulární mechanismy buněčné signalizace (zejména struktura a funkce signálních systémů receptorů spřažených s G proteiny), zkoumání molekulárních mechanismů kardioprotektivního působení chronické hypoxie, chladové adaptace nebo ischemického preconditioningu, studium buněčné signalizace, cytoprotekce, oxidativního stresu a apoptózy v souvislosti s působením opioidů

Vybrané publikace za posledních 5 let

Trubacova R, Drastichova Z, Novotny J. (2022) Biochemical and physiological insights into TRH receptor-mediated signaling. Front Cell Dev Biol. 0:981452. doi: 10.3389/fcell.2022.981452. Review

Rudajev V, Novotny J. (2022) Cholesterol as a key player in amyloid β-mediated toxicity in Alzheimer's disease. Front Mol Neurosci. 15:937056. doi: 10.3389/fnmol.2022.937056. Review

Drastichova Z, Trubacova R, Novotny J. (2022) β-Arrestin2 Is Critically Involved in the Differential Regulation of Phosphosignaling Pathways by Thyrotropin-Releasing Hormone and Taltirelin. Cells. 11(9):1473. doi: 10.3390/cells11091473.

Moravcova S, Spisska V, Pacesova D, Hrubcova L, Kubistova A, Novotny J, Bendova Z. (2022) Circadian control of kynurenine pathway enzymes in the rat pineal gland, liver, and heart and tissue- and enzyme-specific responses to lipopolysaccharide. Arch Biochem Biophys. 722:109213. doi: 10.1016/j.abb.2022.109213. 

Pacesova D, Spisska V, Novotny J, Bendova Z. (2022) Circadian rhythms of locomotor activity in rats: Data on the effect of morphine administered from the early stages of embryonic development until weaning Data Brief. 40:107812. doi: 10.1016/j.dib.2022.107812.

Moravcova S, Filipovska E, Spisska V, Svobodova I, Novotny J, Bendova Z. (2021) Life (Basel). 11(10):1105. doi: 10.3390/life11101105.

Pačesová D, Spišská V, Novotný J, Bendová Z. (2021) Maternal morphine intake during pregnancy and lactation affects the circadian clock of rat pups.Brain Res Bull. 177:143-154. doi: 10.1016/j.brainresbull.2021.09.016. 

Cockova Z, Honc O, Telensky P, Olsen MJ, Novotny J. (2021) Streptozotocin-Induced Astrocyte Mitochondrial Dysfunction Is Ameliorated by FTO Inhibitor MO-I-500. ACS Chem Neurosci. 12(20):3818-3828. doi: 10.1021/acschemneuro.1c00063. 

Ujcikova H, Eckhardt A, Hejnova L, Novotny J, Svoboda P. (2021) Alterations in the Proteome and Phosphoproteome Profiles of Rat Hippocampus after Six Months of Morphine Withdrawal: Comparison with the Forebrain Cortex. Biomedicines. 10(1):80. doi: 10.3390/biomedicines10010080.

Markova V, Hejnova L, Benda A, Novotny J, Melkes B. (2021) β-Arrestin 1 and 2 similarly influence μ-opioid receptor mobility and distinctly modulate adenylyl cyclase activity. Cell Signal. 87:110124. doi: 10.1016/j.cellsig.2021.110124

Neckář J, Alánová P, Olejníčková V, Papoušek F, Hejnová L, Šilhavý J, Behuliak M, Bencze M, Hrdlička J, Vecka M, Jarkovská D, Švíglerová J, Mistrová E, Štengl M, Novotný J, Ošťádal B, Pravenec M, Kolář F. (2021) Excess ischemic tachyarrhythmias trigger protection against myocardial infarction in hypertensive rats. Clin Sci (Lond). 135(17):2143-2163. doi: 10.1042/CS20210648.

Honetschlagerová Z, Gawrys O, Jíchová Š, Škaroupková P, Kikerlová S, Vaňourková Z, Husková Z, Melenovský V, Kompanowska-Jezierska E, Sadowski J, Kolář F, Novotný J, Hejnová L, Kujal P, Červenka L. (2021) Renal Sympathetic Denervation Attenuates Congestive Heart Failure in Angiotensin II-Dependent Hypertension: Studies with Ren-2 Transgenic Hypertensive Rats with Aortocaval Fistula. Kidney Blood Press Res. 46(1):95-113. doi: 10.1159/000513071. 

Moravcová S, Červená K, Míková H, Pačesová D, Pallag G, Novotný J, Bendová Z. (2021) Social defeat stress affects resident's clock gene and bdnf expression in the brain. Stress. 24(2):206-212. doi: 10.1080/10253890.2020.1759548. 

Tibenska V, Marvanova A, Elsnicova B, Hejnova L,  Vebr P, Novotný J, Kolar F, Novakova O, Zurmanova JM. (2021) The cardioprotective effect persisting during recovery from cold acclimation is mediated by the β 2-adrenoceptor pathway and Akt activation. J Appl Physiol (1985).;130(3):746-755. 

Drastichova Z, Rudajev V, Pallag G, Novotny J. (2021) Proteome profiling of different rat brain regions reveals the modulatory effect of prolonged maternal separation on proteins involved in cell death-related processes. Biol Res. 54(1):4. doi: 10.1186/s40659-021-00327-5.

Drastichova Z, Hejnova L, Moravcova R, Novotny J. (2021) Proteomic Analysis Unveils Expressional Changes in Cytoskeleton- and Synaptic Plasticity-Associated Proteins in Rat Brain Six Months after Withdrawal from Morphine. Life (Basel). 11(7):683. doi: 10.3390/life11070683.

Tibenská V, Benesova A, Vebr P, Liptáková A, Hejnová L, Elsnicová B, Drahota Z, Hornikova D, Galatík F, Kolar D, Vybiral S, Alánová P, Novotný J, Kolar F, Novakova O, Zurmanova JM. (2020) Gradual cold acclimation induces cardioprotection without affecting beta-adrenergic receptor-mediated adenylyl cyclase signaling. J Appl Physiol (1985).;128(4):1023-1032.

Rudajev V, Novotny J. (2020) The Role of Lipid Environment in Ganglioside GM1-Induced Amyloid β Aggregation. Membranes (Basel). Sep 9;10(9):226.

Spišská V, Pačesová D, Míková H, Pohanová P, Telenský P, Novotný J, Bendová Z. (2020) Prenatal exposure to lipopolysaccharide induces changes in the circadian clock in the SCN and AA-NAT activity in the pineal gland. Brain Res. 1743:146952. doi: 10.1016/j.brainres.2020.146952. 

Bendová Z, Pačesová D, Novotný J. (2020) The day-night differences in ERK1/2, GSK3β activity and c-Fos levels in the brain, and the responsiveness of various brain structures to morphine. J Comp Neurol. 528(14):2471-2495. doi: 10.1002/cne.24906. 

Melkes B, Markova V, Hejnova L, Marek A, Novotny J. (2020) Naloxone Is a Potential Binding Ligand and Activator of the Capsaicin Receptor TRPV1. Biol Pharm Bull. 43(5):908-912. doi: 10.1248/bpb.b19-00806.

Melkes B, Markova V, Hejnova L, Novotny J. (2020) β-Arrestin 2 and ERK1/2 Are Important Mediators Engaged in Close Cooperation between TRPV1 and µ-Opioid Receptors in the Plasma Membrane. Int J Mol Sci. 21(13):4626. doi: 10.3390/ijms21134626.

Filipovská E, Červená K, Moravcová S, Novotný J, Kyclerová H, Spišská V, Pačesová D, Bendová Z. (2019) The effect of the cannabinoid receptor agonist and antagonist on the light-induced changes in the suprachiasmatic nucleus of rats. Neurosci Lett. 703:49-52. doi: 10.1016/j.neulet.2019.03.022. 

Cockova Z, Ujcikova H, Telensky P, Novotny J. (2019) Protein profiling of SH-SY5Y neuroblastoma cells: The effect of rhein. J Biosci. 44(4):88.

Manakov D, Kolar D, Zurmanova J, Pravenec M, Novotny J. (2018) Changes in the activity of some metabolic enzymes in the heart of SHR rat incurred by transgenic expression of CD36. J Physiol Biochem. [Epub ahead of print] PubMed PMID: 29916179.

Nedvedova I, Kolar D, Elsnicova B, Hornikova D, Novotny J, Kalous M, Pravenec M, Neckar J, Kolar F, Zurmanova JM. (2018) Mitochondrial genome modulates myocardial Akt/GLUT/HK salvage pathway in spontaneously hypertensive rats adapted to chronic hypoxia.  Physiol Genomics. 50(7):532-541.

Skrabalova J, Karlovska I, Hejnova L, Novotny J. (2018) Protective Effect of Morphine Against the Oxidant-Induced Injury in H9c2 Cells. Cardiovasc Toxicol. 18(4):374-385. doi: 10.1007/s12012-018-9448-0.

Moravcová S, Pačesová D, Melkes B, Kyclerová H, Spišská V, Novotný J, Bendová Z. (2018) The day/night difference in the circadian clock's response to acute lipopolysaccharide and the rhythmic Stat3 expression in the rat suprachiasmatic nucleus. PLoS One. 2018 Sep 28;13(9):e0199405. doi: 10.1371/journal.pone.0199405. eCollection 2018.

Hahnova K, Brabcova I, Neckar J, Weissova R, Svatonova A, Novakova O, Zurmanova J, Kalous M, Silhavy J, Pravenec M, Kolar F, Novotny J. (2018) β-Adrenergic signaling, monoamine oxidase A and antioxidant defence in the myocardium of SHR and SHR-mtBN conplastic rat strains: the effect of chronic hypoxia. J Physiol Sci. 68(4):441-454.